Frederick W. Alt's Advances in Immunology, Vol. 102 PDF

By Frederick W. Alt

ISBN-10: 0123748011

ISBN-13: 9780123748010

Advances in Immunology, a original and hugely revered ebook, offers present advancements in addition to complete experiences in immunology. Articles tackle the wide variety of subject matters that contain immunology, together with molecular and mobile activation mechanisms, phylogeny and molecular evolution, and scientific modalities. Edited and authored by way of the main scientists within the box, each one quantity offers up to date details and instructions for destiny * Contributions from major gurus and specialists * Informs and updates on the entire most modern advancements within the box

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Download PDF by Frederick W. Alt: Advances in Immunology, Vol. 102

Advances in Immunology, a original and hugely revered booklet, offers present advancements in addition to complete experiences in immunology. Articles deal with the wide variety of issues that include immunology, together with molecular and mobile activation mechanisms, phylogeny and molecular evolution, and scientific modalities.

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Recently, DCs recognizing nucleic acids though TLR7 and TLR9 were shown to activate iNKT cells. , 2007). , 2007). In addition to creating an inflammatory cytokine milieu, detection of microbes by APCs causes the APC to mature and become more efficient at presenting self-lipids to iNKT cells. Recognition of bacterial products from Escherichia coli or S. typhimurium, or infection with M. , 2005). Furthermore, TLR-stimulated APCs modulate their lipid biosynthetic pathways, leading to substitution of weak CD1d-presented self-antigen for more potent endogenous agonists of iNKT cells.

1. Deployment of CD1d-restricted T cells While the localization and trafficking of dNKT cells has been difficult to assess owing to lack of selective markers, iNKT cells, which can be tracked using a-GalCer-loaded CD1d tetramers, exhibit distinctive tissue distribution and recruitment patterns. 1. 5% of lymphocytes in primary and secondary lymphoid organs and lymphoid tissues, as determined by a-GalCer-loaded CD1d tetramer staining. , 2005). iNKT cells are less abundant in humans, and their tissue distribution remains poorly characterized.

2006). , 2008). While these differences suggest that physiological lipid antigens may also skew iNKT cell responses, why structural variations affect the cytokines secreted is unclear. , 2004). , 2005), thus, preferential uptake of different lipids by different cells may also explain specific iNKT cell skewing. , 1999; Nagarajan and Kronenberg, 2007). , 2005). 5. ROLE OF CD1d-RESTRICTED NKT CELLS IN SPECIFIC MICROBIAL INFECTIONS A number of studies have assessed the roles of CD1d-restricted T cells in immunity to microbial infections.

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Advances in Immunology, Vol. 102 by Frederick W. Alt


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